Association between shortened leukocyte telomere length and cardio-metabolic outcomes.
نویسندگان
چکیده
In their meta-analysis of 27 published studies, D’Mello et al show that shortened leukocyte telomere length (LTL) is associated with 3 primary end points: myocardial infarction, stroke, and type 2 diabetes mellitus. The meta-analysis and its findings raise several fundamental issues that are worth considering. After discussing the major findings and limitations, we focus on 3 central themes: the reliability of LTL measurements, the biological meaning of the association of LTL with cardio-metabolic outcomes, and future directions of telomere research with respect to cardiovascular disease (CVD) and longevity in humans.
منابع مشابه
Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis.
BACKGROUND Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length is hypothesized to be a novel biomarker for age and age-related diseases, yet reports on its associ...
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ورودعنوان ژورنال:
- Circulation. Cardiovascular genetics
دوره 8 1 شماره
صفحات -
تاریخ انتشار 2015